More Cov2 research and my assertions -
My general thinking is that the Cov2 is creating Antibody Dependent Enhancement. Since the current studies don't seem to specifically support ADE in humans, we need to look all the way back to 2007 when research was completed to add to the SARS Cov1 virus to make it more lethal for studies in mice. As it were, the mice studies were not yielding the information required because mice recovered too quickly. To solve that problem the wizard scientists enhanced Cov1 with 6 additional sequences. As a result Cov1 was now lethal for mice. Flash forward to 2021. Cov2 jumps from people to mice, grabs the additional sequences along with the ADE traits and then jumps back to people. Sars Cov2 is now ADE susceptible in human populations; aka Omicron -
https://www.researchgate.net/.../357009821_Distinct...
strategies aga…
See more
RESEARCHGATE.NET
www.researchgate.net
Is there any reason to believe that findings concerning SARS-CoV generalize to SARS-CoV-2? There are many coronaviruses, and they certainly don't all behave the same.
https://www.ijidonline.com/.../S1201-9712(20.../fulltext
- Antibody-dependent
enhancement (ADE) exists in several kinds of virus. It has a negative influence
on antibody therapy for viral infection. This effect was first identified in
dengue v…
See more
IJIDONLINE.COM
Antibody-dependent enhancement of coronavirus
Antibody-dependent enhancement of coronavirus
Dr. Been provides a good explanation of the mechanism of ADE - unfortunately the study he references is removed - https://www.youtube.com/watch?v=oCt9v_usTkc
YOUTUBE.COM
5 Mechanisms of ADE (How Does Antibody-Dependent
Enhancement Occur?)
5 Mechanisms of ADE (How Does Antibody-Dependent Enhancement Occur?)And here is a study from 2007
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1769406/
when they were studying
SARS-COV1 and decided they needed to make it more infectious and lethal so it
would kill mice so they could better study it in humans - currently there is a
theory and study that Omicron jumped from humans to mice and back to humans
- https://www.sciencedirect.com/.../pii/S1673852721003738...
While the proof for ADE
in humans is currently speculative, it is not zero. ADE does occur in mouse
study models - Author Summary
Severe acute respiratory
syndrome (SARS) is a severe, sometimes fatal respiratory disease caused by a
coronavirus (SARS-CoV). In order to study the disease and evaluate vaccines and
antiviral drugs, animal models that mimic the disease are necessary. However,
no single animal model for SARS reproduces all aspects of the disease as it
affects humans. SARS-CoV replicates in the lungs of young mice, but they do not
show signs of illness. Adaptation of SARS-CoV by serial passage in the lungs of
mice resulted in a virus (MA15) that is lethal for young mice following
intranasal inoculation. Lethality is preceded by rapid and high titer viral
replication in lungs, viremia, and dissemination of virus to extrapulmonary
sites accompanied by hematological changes and pathological changes in the
lungs. Mice infected with MA15 virus die from an overwhelming viral infection
with extensive, virally mediated destruction of pneumocytes, and ciliated
epithelial cells. The MA15 virus has six coding mutations in its genome, which,
when introduced into a recombinant SARS-CoV, confer lethality. The MA15 virus
will enhance the use of the mouse model for SARS because infection with this
virus in mice reproduces many aspects of severe human disease, including
morbidity, mortality, and pulmonary pathology.
NCBI.NLM.NIH.GOV
A Mouse-Adapted SARS-Coronavirus Causes Disease and
Mortality in BALB/c Mice
A Mouse-Adapted SARS-Coronavirus Causes Disease and Mortality in BALB/c Mice
And this article I pulled out
of a recent compendium may be the smoking gun - https://www.journalofinfection.com/.../S0163.../fulltext
JOURNALOFINFECTION.COM
Infection-enhancing anti-SARS-CoV-2 antibodies
recognize both the original Wuhan/D614G strain and Delta variants. A potential
risk for mass vaccination?
And the compendium - https://palexander.substack.com/.../vaccine-failure-on...
PALEXANDER.SUBSTACK.COM
Vaccine failure on Delta and Omicron: I pulled
together over 35 studies showing the vaccine has failed and see the BROWNSTONE
op-ed; we cant get these in medical journals, blacklisted so I use op-eds.
Comments
Post a Comment