In 2016 the scientific community was aware that using the spike protein to create SARS-COV vaccines was likely to cause Antibody dependent enhancement.

 

https://www.sciencedirect.com/.../pii/S2055664020312164...

"We suggested that antibodies against spike proteins of SARS-CoV may cause ADE effect. This data raises reasonable concern regarding the use of SARS-CoV vaccine and shed light on some roles in SARS pathogenesis."

 

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